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Cell growth in aggregates determines gene expression, proliferation, survival and chemoresistance of Follicular Lymphoma

ABSTRACT: Cell growth in aggregates determines gene expression, proliferation, survival and chemoresistance of Follicular Lymphoma

PROVIDER: PRJNA178327 | ENA |

REPOSITORIES: ENA

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Cell growth in aggregates determines gene expression, proliferation, survival and chemoresistance of Follicular Lymphoma

Project description:This SuperSeries is composed of the following subset Series: GSE41851: Expression data from follicular lymphoma cells cultured either in suspension either as Multicellular aggregates of lymphoma cells (MALC) GSE41855: Expression data from quiescent cells and cycling cells isolated from Multicellular aggregates of lymphoma cells (MALC) Refer to individual Series

2012-10-27 | E-GEOD-41856 | biostudies-arrayexpress

Cell growth in aggregates determines gene expression, proliferation, survival and chemoresistance of Follicular Lymphoma

Project description:This SuperSeries is composed of the SubSeries listed below.

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Expression data from follicular lymphoma cells cultured either in suspension either as Multicellular aggregates of lymphoma cells (MALC)

Project description:Follicular Lymphomas are blood tumors growing as spheres in patients. Before this study, there was no experimental model mimicking the 3D organization of these in vivo tumors. We develop such a model, called MALC, and performed a pan-genomic comparative analysis between MALC and classical suspension cultures. We used microarrays to detail the global gene expression profile induced by aggregated growth of lymphoma cells. 10 days-old MALC and suspension RL cells were selected for RNA extraction and hybridization on Affymetrix U133+ 2.0 microarrays.

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Project description:We used microarrays to detail gene expression profile of several follicular lymphoma patient samples with different grades We analyzed 72 FL samples

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