Dataset Information


Homo sapiens

ABSTRACT: Comparative intraindividual transcriptome analysis of B-precursor ALL of childhood

ORGANISM(S): Homo sapiens  



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Aberrant ZNF423 impedes B cell differentiation and is linked to adverse outcome of ETV6-RUNX1 negative B precursor acute lymphoblastic leukemia.

Harder Lena L   Eschenburg Georg G   Zech Antonia A   Kriebitzsch Neele N   Otto Benjamin B   Streichert Thomas T   Behlich Anna-Sophie AS   Dierck Kevin K   Klingler Bine B   Hansen Arne A   Stanulla Martin M   Zimmermann Martin M   Kremmer Elisabeth E   Stocking Carol C   Horstmann Martin A MA  

The Journal of experimental medicine 20130930 11

Differentiation arrest is a hallmark of acute leukemia. Genomic alterations in B cell differentiation factors such as PAX5, IKZF1, and EBF-1 have been identified in more than half of all cases of childhood B precursor acute lymphoblastic leukemia (ALL). Here, we describe a perturbed epigenetic and transcriptional regulation of ZNF423 in ALL as a novel mechanism interfering with B cell differentiation. Hypomethylation of ZNF423 regulatory sequences and BMP2 signaling result in transactivation of  ...[more]

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