Dataset Information


Homo sapiens

ABSTRACT: Neuropsychiatric and clinical correlates to miRNA expression in the frontal cortex of HIV-infected individuals

ORGANISM(S): Homo sapiens  



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Modulation of BK channel by MicroRNA-9 in neurons after exposure to HIV and methamphetamine.

Tatro Erick T ET   Hefler Shannon S   Shumaker-Armstrong Stephanie S   Soontornniyomkij Benchawanna B   Yang Michael M   Yermanos Alex A   Wren Nina N   Moore David J DJ   Achim Cristian L CL  

Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 20130319 5

MicroRNAs (miR) regulate phenotype and function of neurons by binding to miR-response elements (MRE) in the 3' untranslated regions (3'UTR) of various messenger RNAs to inhibit translation. MiR expression can be induced or inhibited by environmental factors like drug exposure and viral infection, leading to changes in cellular physiology. We hypothesized that the effects of methamphetamine (MA) and human immunodeficiency virus (HIV)-infection in the brain will induce changes in miR expression, a  ...[more]

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