Genomics

Dataset Information

0

Mus musculus


ABSTRACT: Notch Pathway Activation Targets AML Cell Homeostasis and Differentiation: MLL-AF9 transformed LGMP

ORGANISM(S): Mus musculus  

PROVIDER: PRJNA179480 | ENA |

REPOSITORIES: ENA

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Publications


Notch signaling pathway activation is known to contribute to the pathogenesis of a spectrum of human malignancies, including T cell leukemia. However, recent studies have implicated the Notch pathway as a tumor suppressor in myeloproliferative neoplasms and several solid tumors. Here we report a novel tumor suppressor role for Notch signaling in acute myeloid leukemia (AML) and demonstrate that Notch pathway activation could represent a therapeutic strategy in this disease. We show that Notch si  ...[more]

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