Genomics

Dataset Information

0

Mus musculus


ABSTRACT: Characterization of IGF1 effects on the transcriptome of normal and irradiated Sox9-EGFP cell populations

ORGANISM(S): Mus musculus  

PROVIDER: PRJNA183489 | ENA |

REPOSITORIES: ENA

altmetric image

Publications

IGF1 stimulates crypt expansion via differential activation of 2 intestinal stem cell populations.

Van Landeghem Laurianne L   Santoro M Agostina MA   Mah Amanda T AT   Krebs Adrienne E AE   Dehmer Jeffrey J JJ   McNaughton Kirk K KK   Helmrath Michael A MA   Magness Scott T ST   Lund P Kay PK  

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20150402 7


Insulin-like growth factor 1 (IGF1) has potent trophic effects on normal or injured intestinal epithelium, but specific effects on intestinal stem cells (ISCs) are undefined. We used Sox9-enhanced green fluorescent protein (EGFP) reporter mice that permit analyses of both actively cycling ISCs (Sox9-EGFP(Low)) and reserve/facultative ISCs (Sox9-EGFP(High)) to study IGF1 action on ISCs in normal intestine or during crypt regeneration after high-dose radiation-induced injury. We hypothesized that  ...[more]

Similar Datasets

2015-04-14 | E-GEOD-42817 | ArrayExpress
2012-06-17 | E-GEOD-32227 | ArrayExpress
| GSE81125 | GEO
| GSE76179 | GEO
| PRJNA398384 | ENA
2012-08-01 | E-GEOD-34060 | ArrayExpress
| GSE35898 | GEO
2011-02-16 | E-MTAB-537 | ArrayExpress
2013-03-09 | E-MTAB-1192 | ArrayExpress
| PRJNA147207 | ENA