Dataset Information


Mus musculus

ABSTRACT: Characterization of IGF1 effects on the transcriptome of normal and irradiated Sox9-EGFP cell populations

ORGANISM(S): Mus musculus  



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IGF1 stimulates crypt expansion via differential activation of 2 intestinal stem cell populations.

Van Landeghem Laurianne L   Santoro M Agostina MA   Mah Amanda T AT   Krebs Adrienne E AE   Dehmer Jeffrey J JJ   McNaughton Kirk K KK   Helmrath Michael A MA   Magness Scott T ST   Lund P Kay PK  

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20150402 7

Insulin-like growth factor 1 (IGF1) has potent trophic effects on normal or injured intestinal epithelium, but specific effects on intestinal stem cells (ISCs) are undefined. We used Sox9-enhanced green fluorescent protein (EGFP) reporter mice that permit analyses of both actively cycling ISCs (Sox9-EGFP(Low)) and reserve/facultative ISCs (Sox9-EGFP(High)) to study IGF1 action on ISCs in normal intestine or during crypt regeneration after high-dose radiation-induced injury. We hypothesized that  ...[more]

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