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MicroRNA regulate immunological pathways in T-cells in immune thrombocytopenia (ITP)

ABSTRACT: MicroRNA regulate immunological pathways in T-cells in immune thrombocytopenia (ITP)

PROVIDER: PRJNA184850 | ENA |

REPOSITORIES: ENA

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MicroRNA regulate immunological pathways in T-cells in immune thrombocytopenia (ITP) [miRNA]

Project description:MicroRNA are small non-coding RNA molecules that regulate gene expression. To investigate the role of microRNA in ITP, we performed genome-wide expression analyses of mRNA and microRNA in T-cells from ITP patients and controls. We identified 1,915 regulated genes and 22 regulated microRNA that differed between ITP patients and controls. Seventeen of the 22 regulated microRNA were linked to changes in target gene expression; 57 of these target genes were associated with the immune system, e.g. T-cell activation and regulation of immunoglobulin production. CXCL13 and IL-21 were two microRNA target genes significantly increased in ITP. We could demonstrate increased plasma levels of CXCL13 and others have reported increased plasma levels of IL-21 in ITP. Thus, regulated microRNA were significantly associated with both gene and protein expression of molecules in immunological pathways. We suggest that microRNA may be important regulatory molecules involved in the loss of tolerance in ITP. Microarray expression analysis of mRNA and miRNA in peripheral blood T-cell of control and ITP patients.

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MicroRNA regulate immunological pathways in T-cells in immune thrombocytopenia (ITP).

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Differential expression of plasma miRNAs in immune thrombocytopenia

Project description:We investigated the expression profiles of plasma miRNAs in immune thrombocytopenia (ITP) patients. Peripheral blood plasma was used for Agilent miRNA expression microarray analysis to define miRNA profiles and to identify miRNAs with discriminatory levels for ITP and healthy controls. Results were further validated using quantitative realtime PCR on a larger cohort, enabling relative quantification of plasma miRNAs and defining miRNAs with diagnostic value for the disease.

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MicroRNA regulate immunological pathways in T-cells in immune thrombocytopenia (ITP)

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

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MicroRNA regulate immunological pathways in T-cells in immune thrombocytopenia (ITP)

Project description:This SuperSeries is composed of the SubSeries listed below.

2013-01-22 | GSE43179 | GEO