Dataset Information


Homo sapiens

ABSTRACT: Differentially expressed genes in H2AX knockdown cells undergoing apoptosis

ORGANISM(S): Homo sapiens  



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Genome-wide transcriptional analysis of apoptosis-related genes and pathways regulated by H2AX in lung cancer A549 cells.

Lu Chengrong C   Xiong Min M   Luo Yuan Y   Li Jing J   Zhang Yanjun Y   Dong Yaqiong Y   Zhu Yanjun Y   Niu Tianhui T   Wang Zhe Z   Duan Lianning L  

Apoptosis : an international journal on programmed cell death 20130901 9

Histone H2AX is a novel tumor suppressor protein and plays an important role in apoptosis of cancer cells. However, the role of H2AX in lung cancer cells is unclear. The detailed mechanism and epigenetic regulation by H2AX remain elusive in cancer cells. We showed that H2AX was involved in apoptosis of lung cancer A549 cells as in other tumor cells. Knockdown of H2AX strongly suppressed apoptosis of A549 cells. We clarified the molecular mechanisms of apoptosis regulated by H2AX based on genome-  ...[more]

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