Genomics

Dataset Information

118

Co-ordinate inhibition of autism candidate genes by topoisomerase inhibitors [Seq]


ABSTRACT: Co-ordinate inhibition of autism candidate genes by topoisomerase inhibitors [Seq]

PROVIDER: PRJNA186671 | ENA |

REPOSITORIES: ENA

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Publications


Topoisomerases are expressed throughout the developing and adult brain and are mutated in some individuals with autism spectrum disorder (ASD). However, how topoisomerases are mechanistically connected to ASD is unknown. Here we find that topotecan, a topoisomerase 1 (TOP1) inhibitor, dose-dependently reduces the expression of extremely long genes in mouse and human neurons, including nearly all genes that are longer than 200 kilobases. Expression of long genes is also reduced after knockdown of  ...[more]

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