Genomics

Dataset Information

118

Epigenetic conservation at gene regulatory elements revealed by non-methylated DNA profiling in seven vertebrates


ABSTRACT: Epigenetic conservation at gene regulatory elements revealed by non-methylated DNA profiling in seven vertebrates

PROVIDER: PRJNA186672 | ENA |

REPOSITORIES: ENA

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Publications

Protection of CpG islands from DNA methylation is DNA-encoded and evolutionarily conserved.

Long Hannah K HK   King Hamish W HW   Patient Roger K RK   Odom Duncan T DT   Klose Robert J RJ  

Nucleic acids research 20160415 14


DNA methylation is a repressive epigenetic modification that covers vertebrate genomes. Regions known as CpG islands (CGIs), which are refractory to DNA methylation, are often associated with gene promoters and play central roles in gene regulation. Yet how CGIs in their normal genomic context evade the DNA methylation machinery and whether these mechanisms are evolutionarily conserved remains enigmatic. To address these fundamental questions we exploited a transchromosomic animal model and geno  ...[more]

Publication: 1/2

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