Genomics

Dataset Information

59

Mus musculus


ABSTRACT: Effects of overexpressed Atoh8 on the transcriptional profile of mouse ductal cells mPAC in the absence or presence of co-expressed Neurogenin3

ORGANISM(S): Mus musculus  

PROVIDER: PRJNA186674 | ENA |

REPOSITORIES: ENA

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Publications

Characterization of the transcriptional activity of the basic helix-loop-helix (bHLH) transcription factor Atoh8.

Ejarque Miriam M   Altirriba Jordi J   Gomis Ramon R   Gasa Rosa R  

Biochimica et biophysica acta 20130809 11


The atonal-related Neurogenin/NeuroD family of basic helix-loop-helix (bHLH) transcription factors comprises potent inducers of neuronal and endocrine differentiation programs in the nervous and digestive system. Atonal homolog 8 (Atoh8) displays high similarity in the bHLH domain with NeuroD proteins. Yet, available evidences indicate that Atoh8 has distinctive features including a ubiquitous expression pattern in embryonic tissues and the ability to inhibit differentiation. To gain insights in  ...[more]

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