Dataset Information


Mus musculus

ABSTRACT: Transcriptional responses to GSK3 inhibitor and MEK inhibitor on 2i-adapted mouse embryonic stem cells

ORGANISM(S): Mus musculus  



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Gene regulatory networks mediating canonical Wnt signal-directed control of pluripotency and differentiation in embryo stem cells.

Zhang Xiaoxiao X   Peterson Kevin A KA   Liu X Shirley XS   McMahon Andrew P AP   Ohba Shinsuke S  

Stem cells (Dayton, Ohio) 20131201 12

Canonical Wnt signaling supports the pluripotency of embryonic stem cells (ESCs) but also promotes differentiation of early mammalian cell lineages. To explain these paradoxical observations, we explored the gene regulatory networks at play. Canonical Wnt signaling is intertwined with the pluripotency network comprising Nanog, Oct4, and Sox2 in mouse ESCs. In defined media supporting the derivation and propagation of ESCs, Tcf3 and β-catenin interact with Oct4; Tcf3 binds to Sox motif within Oct  ...[more]

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