Dataset Information


Mus musculus

ABSTRACT: Effect of Oleanolic acid on liver transcriptome of mice lacking apolipoprotein E

ORGANISM(S): Mus musculus  



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Dietary oleanolic acid mediates circadian clock gene expression in liver independently of diet and animal model but requires apolipoprotein A1.

Gabás-Rivera Clara C   Martínez-Beamonte Roberto R   Ríos José L JL   Navarro María A MA   Surra Joaquín C JC   Arnal Carmen C   Rodríguez-Yoldi María J MJ   Osada Jesús J  

The Journal of nutritional biochemistry 20131201 12

Oleanolic acid is a triterpene widely distributed throughout the plant kingdom and present in virgin olive oil at a concentration of 57 mg/kg. To test the hypotheses that its long-term administration could modify hepatic gene expression in several animal models and that this could be influenced by the presence of APOA1-containing high-density lipoproteins (HDLs), diets including 0.01% oleanolic acid were provided to Apoe- and Apoa1-deficient mice and F344 rats. Hepatic transcriptome was analyzed  ...[more]

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