Dataset Information


Homo sapiens

ABSTRACT: Global gene expression analysis in macrophages treated with Nutlin-3

ORGANISM(S): Homo sapiens  



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p53 and NF-κB coregulate proinflammatory gene responses in human macrophages.

Lowe Julie M JM   Menendez Daniel D   Bushel Pierre R PR   Shatz Maria M   Kirk Erin L EL   Troester Melissa A MA   Garantziotis Stavros S   Fessler Michael B MB   Resnick Michael A MA  

Cancer research 20140401 8

Macrophages are sentinel immune cells that survey the tissue microenvironment, releasing cytokines in response to both exogenous insults and endogenous events such as tumorigenesis. Macrophages mediate tumor surveillance and therapy-induced tumor regression; however, tumor-associated macrophages (TAM) and their products may also promote tumor progression. Whereas NF-κB is prominent in macrophage-initiated inflammatory responses, little is known about the role of p53 in macrophage responses to en  ...[more]

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