Genomics

Dataset Information

118

Mus musculus


ABSTRACT: Genome-wide localization of Smc1, Smc3 and CTCF in mouse B cells.

ORGANISM(S): Mus musculus  

PROVIDER: PRJNA186794 | ENA |

REPOSITORIES: ENA

altmetric image

Publications

The cohesin complex regulates immunoglobulin class switch recombination.

Thomas-Claudepierre Anne-Sophie AS   Schiavo Ebe E   Heyer Vincent V   Fournier Marjorie M   Page Adeline A   Robert Isabelle I   Reina-San-Martin Bernardo B  

The Journal of experimental medicine 20131021 12


Immunoglobulin (Ig) class switch recombination (CSR) is initiated by the transcription-coupled recruitment of activation-induced cytidine deaminase (AID) to switch regions and by the subsequent generation of double-stranded DNA breaks (DSBs). These DNA breaks are ultimately resolved through the nonhomologous end joining (NHEJ) pathway. We show that during CSR, AID associates with subunits of cohesin, a complex previously implicated in sister chromatid cohesion, DNA repair, and the formation of D  ...[more]

Similar Datasets

| GSE76303 | GEO
2015-07-30 | MODEL1507180055 | BioModels
2015-07-30 | MODEL1507180042 | BioModels
2017-04-04 | PXD005897 | Pride
| PRJNA137869 | ENA
2009-05-20 | GSE16139 | GEO
2004-01-02 | GSE887 | GEO
2012-03-15 | E-GEOD-32319 | ArrayExpress
| PRJNA289508 | ENA
2013-08-09 | E-GEOD-41602 | ArrayExpress