Rattus norvegicus
Ontology highlight
ABSTRACT:
OTHER RELATED OMICS DATASETS IN: E-GEOD-43671
PROVIDER: PRJNA187063 | ENA |
REPOSITORIES: ENA
Similar Datasets
Project description:Time-Dependent Gene Profiling Indicates the Presence of Different Phases for Ischemia/Reperfusion Injury in Retina
2015-07-10 | E-GEOD-43671 | ExpressionAtlas
Project description:Time-Dependent miRNA Profiling Following Ischemia/Reperfusion Injury in Rat Retina
| PRJNA260187 | ENA
Project description:Heart disease remains the leading cause of death globally. Although reperfusion following myocardial ischemia can prevent death by restoring nutrient flow, ischemia/reperfusion injury can cause significant heart damage. The mechanisms that drive ischemia/reperfusion injury are not well understood; currently, few methods can predict the state of the cardiac muscle cell and its metabolic conditions during ischemia. Here, we explored the energetic sustainability of cardiomyocytes, using a model for cellular metabolism to predict the levels of ATP following hypoxia. We modeled glycolytic metabolism with a system of coupled ordinary differential equations describing the individual metabolic reactions within the cardiomyocyte over time. Reduced oxygen levels and ATP consumption rates were simulated to characterize metabolite responses to ischemia. By tracking biochemical species within the cell, our model enables prediction of the cell’s condition up to the moment of reperfusion. The simulations revealed a distinct transition between energetically sustainable and unsustainable ATP concentrations for various energetic demands. Our model illustrates how even low oxygen concentrations allow the cell to perform essential functions. We found that the oxygen level required for a sustainable level of ATP increases roughly linearly with the ATP consumption rate. An extracellular O2 concentration of ~0.007 mM could supply basic energy needs in non-beating cardiomyocytes, suggesting that increased collateral circulation may provide an important source of oxygen to sustain the cardiomyocyte during extended ischemia. Our model provides a time-dependent framework for studying various intervention strategies to change the outcome of reperfusion.
2020-08-25 | BIOMD0000000961 | BioModels
Project description:Intralipid protects the heart in late pregnancy against ischemia/reperfusion injury
| PRJNA311228 | ENA
Project description:Vascular Permeability and Apoptosis are Separable Processes in Retinal Ischemia-Reperfusion Injury
| PRJNA125249 | ENA
Project description:The transcriptional response to unilateral nephrectomy with and without ischemia-reperfusion injury
| PRJNA392078 | ENA
Project description:Fibrinogen is upregulated following kidney damage and protects it against ischemia-reperfusion injury
| PRJNA137139 | ENA
Project description:Renoprotective Effects of Valproic Acid and Dexamethasone in Acute Kidney Ischemia-Reperfusion Injury
| PRJNA252608 | ENA
Project description:MicroRNA Profiling in Ischemia-Reperfusion Injury of the Gracilis Muscle in Rats (miRNA data)
| PRJNA129497 | ENA