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Gut metagenome strain:Syrian Golden Hamster

ABSTRACT: Mesocricetus auratus Metagenome

PROVIDER: PRJNA188111 | ENA |

REPOSITORIES: ENA

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Changes in golden Syrian hamster HDL proteome caused by altered cholesteryl ester transfer protein expression

Project description:Cholesteryl ester transfer protein (CETP) transfers cholesteryl ester (CE) and triglyceride (TG) between lipoproteins, which alters lipoprotein metabolism. Hamster and human CETPs have very different preferences for CE versus TG as substrate. To assess the impact of altering CETP’s substrate preference on lipoproteins in vivo, human CETP was expressed in hamsters (Mesocricetus auratus). Chow-fed hamsters received adenoviruses expressing no CETP (Ad-Null), hamster CETP (Ad-hamster CETP) or human CETP (Ad-human CETP). High density lipoproteins were isolated from hamster plasma 6 days after adenovirus injection by ultracentrifugation as the 1.063 - 1.21 g/ml density fraction. HDL proteins were precipitated with cold acetone and subjected to LC+MS/MS analysis

2020-06-25 | PXD017998 | Pride

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Gene expresssion changes associated to diet induced fatty liver in hamster

Project description:Our aim was to study the gene expression changes associated to the development of non hepatic steatohepatitis from simple steatosis in a model of diet induced obesity in hamster (mesocricetus auratus)

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Liver transcriptomic and methylomic analyses identify transcriptional MAPK regulation in facultative hibernation of Syrian hamster [WGBS]

Project description:Hibernation consist of alternating torpor/arousal phases, during which animals cope with repetitive hypothermia and ischemia-reperfusion. Due to limited transcriptomic and methylomic information for facultative hibernators, we here conducted RNA and whole genome bisulfite sequencing in liver of hibernating Syrian hamster (Mesocricetus auratus). Gene Ontology analysis was performed on 844 differentially expressed genes (DEGs) and confirmed the shift in metabolic fuel utilization, inhibition of RNA transcription and cell cycle regulation as found in seasonal hibernators. We show a so far unreported suppression of MAPK and PP1 pathways. Notably, hibernating hamsters showed upregulation of MAPK inhibitors (DUSPs and SPRYs) and reduced levels of MAPK induced transcription factors. Promoter methylation was found to modulate the expression of genes targeted by these transcription factors. In conclusion, we document gene regulation between hibernation phases, which may aid the identification of pathways and targets to prevent organ damage in transplantation or ischemia-reperfusion.

2023-05-02 | GSE199815 | GEO

Liver transcriptomic and methylomic analyses identify transcriptional MAPK regulation in facultative hibernation of Syrian hamster [RNA-Seq]

Project description:Hibernation consist of alternating torpor/arousal phases, during which animals cope with repetitive hypothermia and ischemia-reperfusion. Due to limited transcriptomic and methylomic information for facultative hibernators, we here conducted RNA and whole genome bisulfite sequencing in liver of hibernating Syrian hamster (Mesocricetus auratus). Gene Ontology analysis was performed on 844 differentially expressed genes (DEGs) and confirmed the Liver, shift in metabolic fuel utilization, inhibition of RNA transcription and cell cycle regulation as found in seasonal hibernators. We Liver, show a so far unreported suppression of MAPK and PP1 pathways. Notably, hibernating hamsters Liver, showed upregulation of MAPK inhibitors (DUSPs and SPRYs) and reduced levels of MAPK induced transcription factors. Promoter methylation was found to modulate the expression of genes targeted by these transcription factors. In conclusion, we document gene regulation between hibernation phases, which may aid the identification of pathways and targets to prevent organ damage in transplantation or ischemia-reperfusion.

2023-05-02 | GSE199814 | GEO

Quantitative proteomics of hamster lung tissues infected with SARS-CoV-2 reveal host-factors having implication in the disease pathogenesis and severity

Project description:COVID-19 or severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), appeared first in Wuhan, Hubei, China, has emerged as a global health concern claiming millions of lives worldwide. Syrian golden hamster (Mesocricetus auratus) has emerged as a suitable model as when infected by SARS-CoV-2, manifests lung pathology resembling human COVID-19 patients. In this study, we employed a quantitative approach to study the proteomic changes in the SARS-CoV-2-infected lung tissue. The samples were analyzed using Orbitrap Fusion Tribrid mass spectrometer in triplicates and the data acquired was searched against Mesocricetus auratus protein database which resulted in the identification of nearly 2,000 non-redundant proteins. The outcome of this study will facilitate in discovery of potential candidate biomarkers for predicting disease course and warrants their further validation in human patient samples.

2021-11-03 | PXD024547 | Pride

A Syrian golden hamster model recapitulating ebola hemorrhagic fever.

Project description: Not available

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MicroRNA expression profiles in different tissues from normolipidemic hamster and high-fat diet induced hyperlipidemic hamster (Mesocricetus auratus)

Project description:Hyperlipidemia is one of high risk factors for cardiovascular disease (CVD), whose regulation is known to be mediated also by microRNA-mediated mechanisms. Therefore, the analysis of transcriptomics data would gain insights into the molecular mechanisms implicating microRNAs (miRNAs) behind the atherogenic hyperlipidemia. The goal of our study was to profile the specific miRNAs expression associated with atherogenic hyperlipidemia. To this aim, we performed miRNAs microarray analysis for different tissues (liver, left ventricle of the heart, small intestine and blood mononuclear cells) obtained from the experimental model of high-fat diet induced hyperlipidemic hamsters (Mesocricetus auratus). The microarray data were obtained using miRCURY LNA microRNA arrays 7 th generation platform with miRBase 19 (Exiqon, Denmark), using total RNA isolated from hyperlipidemic (HL) and normolipidemic (NL) hamsters? tissues and blood cells. The animals were fed for 12 weeks either standard rodent chow supplemented with 3% cholesterol and 15% unsalted butter (HL) or standard rodent chow (NL), with free access to food and water.

2020-11-26 | GSE128226 | GEO

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