Genomics

Dataset Information

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Mus musculus


ABSTRACT: Behavioural and functional characterization of Kv10.1 (Eag1) knockout mice

ORGANISM(S): Mus musculus  

PROVIDER: PRJNA188702 | ENA |

REPOSITORIES: ENA

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Publications


Kv10.1 (Eag1), member of the Kv10 family of voltage-gated potassium channels, is preferentially expressed in adult brain. The aim of the present study was to unravel the functional role of Kv10.1 in the brain by generating knockout mice, where the voltage sensor and pore region of Kv10.1 were removed to render non-functional proteins through deletion of exon 7 of the KCNH1 gene using the '3 Lox P strategy'. Kv10.1-deficient mice show no obvious alterations during embryogenesis and develop normal  ...[more]

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