Genomics,Multiomics

Dataset Information

0

Homo sapiens


ABSTRACT: Induction of IL-17+ T-cells by HIV-Tat protein is mediated via Vascular Endothelial Growth Factor Receptor-2

OTHER RELATED OMICS DATASETS IN: E-GEOD-44460

PROVIDER: PRJNA190028 | ENA |

REPOSITORIES: ENA

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Publications

Induction of IL-17 and nonclassical T-cell activation by HIV-Tat protein.

Johnson Tory P TP   Patel Karan K   Johnson Kory R KR   Maric Dragan D   Calabresi Peter A PA   Hasbun Rodrigo R   Nath Avindra A  

Proceedings of the National Academy of Sciences of the United States of America 20130729 33


Chronic immune activation is a major complication of antiretroviral therapy (ART) for HIV infection and can cause a devastating immune reconstitution inflammatory syndrome (IRIS) in the brain. The mechanism of T-cell activation in this population is not well understood. We found HIV-Tat protein and IL-17-expressing mononuclear cells in the brain of an individual with IRIS. Tat was also present in the CSF of individuals virologically controlled on ART. Hence we examined if Tat protein could direc  ...[more]

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