Dataset Information


Mus musculus

ABSTRACT: Next Generation Sequencing Analysis of Wild Type and Hypomorphic Nkx2-5 mutant heart Transcriptomes

ORGANISM(S): Mus musculus  



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Sequential Binding of MEIS1 and NKX2-5 on the Popdc2 Gene: A Mechanism for Spatiotemporal Regulation of Enhancers during Cardiogenesis.

Dupays Laurent L   Shang Catherine C   Wilson Robert R   Kotecha Surendra S   Wood Sophie S   Towers Norma N   Mohun Timothy T  

Cell reports 20150924 1

The homeobox transcription factors NKX2-5 and MEIS1 are essential for vertebrate heart development and normal physiology of the adult heart. We show that, during cardiac differentiation, the two transcription factors have partially overlapping expression patterns, with the result that as cardiac progenitors from the anterior heart field differentiate and migrate into the cardiac outflow tract, they sequentially experience high levels of MEIS1 and then increasing levels of NKX2-5. Using the Popdc  ...[more]

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