Genomics

Dataset Information

15

Homo sapiens


ABSTRACT: Crizotinib inhibits metabolic inactivation of gemcitabine in ortothopic pancreatic tumors derived from primary cells with c-Met overexpression

ORGANISM(S): Homo sapiens  

PROVIDER: PRJNA190898 | ENA |

REPOSITORIES: ENA

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Publications


Pancreatic ductal adenocarcinoma (PDAC) remains a major unsolved health problem. Most drugs that pass preclinical tests fail in these patients, emphasizing the need of improved preclinical models to test novel anticancer strategies. Here, we developed four orthotopic mouse models using primary human PDAC cells genetically engineered to express firefly- and Gaussia luciferase, simplifying the ability to monitor tumor growth and metastasis longitudinally in individual animals with MRI and high-fre  ...[more]

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