Dataset Information


Mus musculus

ABSTRACT: Ba/F3 cells expressing ETV6-PDGFRb and FIP1L1-PDGFRa treated or not with Glivec

ORGANISM(S): Mus musculus  



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The expression of the tumour suppressor HBP1 is down-regulated by growth factors via the PI3K/PKB/FOXO pathway.

Coomans de Brachène Alexandra A   Bollaert Emeline E   Eijkelenboom Astrid A   de Rocca Serra Audrey A   van der Vos Kristan E KE   Burgering Boudewijn M T BM   Coffer Paul J PJ   Essaghir Ahmed A   Demoulin Jean-Baptiste JB  

The Biochemical journal 20140501 1

Growth factors inactivate the FOXO (forkhead box O) transcription factors through PI3K (phosphoinositide 3-kinase) and PKB (protein kinase B). By comparing microarray data from multiple model systems, we identified HBP1 (high-mobility group-box protein 1) as a novel downstream target of this pathway. HBP1 mRNA was down-regulated by PDGF (platelet-derived growth factor), FGF (fibroblast growth factor), PI3K and PKB, whereas it was up-regulated by FOXO factors. This observation was confirmed in hu  ...[more]

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