Genomics

Dataset Information

235

Monodelphis domestica


ABSTRACT: Chromosome-wide profiling of X-inactivation status and epigenetic regulation in fetal brain

ORGANISM(S): Monodelphis domestica  

PROVIDER: PRJNA193185 | ENA |

REPOSITORIES: ENA

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Publications

Chromosome-wide profiling of X-chromosome inactivation and epigenetic states in fetal brain and placenta of the opossum, Monodelphis domestica.

Wang Xu X   Douglas Kory C KC   Vandeberg John L JL   Clark Andrew G AG   Samollow Paul B PB  

Genome research 20130924 1


Evidence from a few genes in diverse species suggests that X-chromosome inactivation (XCI) in marsupials is characterized by exclusive, but leaky inactivation of the paternally derived X chromosome. To study the phenomenon of marsupial XCI more comprehensively, we profiled parent-of-origin allele-specific expression, DNA methylation, and histone modifications in fetal brain and extra-embryonic membranes in the gray, short-tailed opossum (Monodelphis domestica). The majority of X-linked genes (15  ...[more]

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