Genomics

Dataset Information

0

Homo sapiens


ABSTRACT: The genomic landscape of small intestine neuroendocrine tumors [CGH]

ORGANISM(S): Homo sapiens  

PROVIDER: PRJNA193189 | ENA |

REPOSITORIES: ENA

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Publications


Small intestine neuroendocrine tumors (SI-NETs) are the most common malignancy of the small bowel. Several clinical trials target PI3K/Akt/mTOR signaling; however, it is unknown whether these or other genes are genetically altered in these tumors. To address the underlying genetics, we analyzed 48 SI-NETs by massively parallel exome sequencing. We detected an average of 0.1 somatic single nucleotide variants (SNVs) per 106 nucleotides (range, 0-0.59), mostly transitions (C>T and A>G), which sugg  ...[more]

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