Genomics

Dataset Information

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ABSTRACT: An Inhibitor of Mutant IDH1 Delays Growth and Promotes Differentiation of Glioma Cells

PROVIDER: PRJNA193197 | ENA |

REPOSITORIES: ENA

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Publications


The recent discovery of mutations in metabolic enzymes has rekindled interest in harnessing the altered metabolism of cancer cells for cancer therapy. One potential drug target is isocitrate dehydrogenase 1 (IDH1), which is mutated in multiple human cancers. Here, we examine the role of mutant IDH1 in fully transformed cells with endogenous IDH1 mutations. A selective R132H-IDH1 inhibitor (AGI-5198) identified through a high-throughput screen blocked, in a dose-dependent manner, the ability of t  ...[more]

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