Genomics

Dataset Information

118

Evolutionary and ontogenetic changes in RNA editing in human, chimpanzee and macaque brains


ABSTRACT: Evolutionary and ontogenetic changes in RNA editing in human, chimpanzee and macaque brains

PROVIDER: PRJNA193311 | ENA |

REPOSITORIES: ENA

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Evolutionary and ontogenetic changes in RNA editing in human, chimpanzee, and macaque brains.

Li Zhongshan Z   Bammann Hindrike H   Li Mingshuang M   Liang Hongyu H   Yan Zheng Z   Phoebe Chen Yi-Ping YP   Zhao Min M   Khaitovich Philipp P  

RNA (New York, N.Y.) 20131023 12


Adenosine-to-inosine (A-to-I) substitutions are the most common type of RNA editing in mammals. A-to-I RNA editing is particularly widespread in the brain and is known to play important roles in neuronal functions. In this study we investigated RNA-editing changes during human brain development and maturation, as well as evolutionary conservation of RNA-editing patterns across primates. We used high-throughput transcriptome sequencing (RNA-seq) to quantify the RNA-editing levels and assess ontog  ...[more]

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