Genomics

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ABSTRACT: Hox-C9 activates the intrinsic pathway of apoptosis and is associated with spontaneous regression in neuroblastoma

PROVIDER: PRJNA194133 | ENA |

REPOSITORIES: ENA

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Hox-C9 activates the intrinsic pathway of apoptosis and is associated with spontaneous regression in neuroblastoma.

Kocak H H   Ackermann S S   Hero B B   Kahlert Y Y   Oberthuer A A   Juraeva D D   Roels F F   Theissen J J   Westermann F F   Deubzer H H   Ehemann V V   Brors B B   Odenthal M M   Berthold F F   Fischer M M  

Cell death & disease 20130411


Neuroblastoma is an embryonal malignancy of the sympathetic nervous system. Spontaneous regression and differentiation of neuroblastoma is observed in a subset of patients, and has been suggested to represent delayed activation of physiologic molecular programs of fetal neuroblasts. Homeobox genes constitute an important family of transcription factors, which play a fundamental role in morphogenesis and cell differentiation during embryogenesis. In this study, we demonstrate that expression of t  ...[more]

Publication: 1/2

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