Danio rerio
Ontology highlight
ABSTRACT:
PROVIDER: PRJNA194579 | ENA |
REPOSITORIES: ENA
Similar Datasets
Project description:Transcriptional profiling of zebrafish (Danio rerio) livers comparing control untreated fish with fish treated with estrogen [17β-estradiol (E2)] for different time points (4, 12, 24, 48 hours).
2013-06-28 | GSE45562 | GEO
Project description:Innate and adaptive immunity in zebrafish: time course (zebrafish)
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Project description:Host and pathogen interaction: time course [zebrafish]
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Project description:Wound healing process after TBI in zebrafish: time course (zebrafish)
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Project description:mRNA-seq of zebrafish treated with sex hormone 17β-estradiol and aromatase inhibitor exemestane during sex development
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Project description:Transcriptome dynamics in early zebrafish embryogenesis determined by high-resolution time course analysis
| PRJNA325807 | ENA
Project description:Female sex steroid hormones, estradiol-17β (E2) and progesterone (P4) regulate reproductive function and gene expression in a broad range of tissues. Given the central role of the liver in regulating homeostasis including steroid hormone metabolism, we sought to understand how E2-17β and P4 interact to affect global gene expression in liver. Eight ovariectomized cows were randomly assigned to 4 treatment groups applied in a replicated Latin Square design: 1) No hormone supplementation, 2) E2-17β treatment (ear implant), 3) P4 treatment (intravaginal inserts), and 4) E2-17β combined with P4. After 14 d of treatment, liver biopsies were collected, allowing 28 d intervals between periods. Changes in gene expression in the liver biopsies were monitored using Affymetrix bovine-specific arrays. Treatment with E2-17β altered expression of 479 genes, P4 472 genes, and combined treatment significantly altered expression of 468 genes. In total, 578 genes exhibited altered expression including a remarkable number (346 genes) that responded similarly to E2-17β, P4, or combined treatment. Additional evidence for similar gene expression effects of E2-17ß and/or P4 were: principal component analysis placed almost every treatment array at a substantial distance from control arrays; Venn diagrams indicated overall treatment effects for most regulated genes; clustering analysis indicated the two major clusters had all treatments upregulating (cluster 1; 172 genes) or downregulating (cluster 2: 173 genes) expression. Thus, unexpectedly, common biological pathways are regulated by E2-17β and/or P4 in liver. Future studies are needed to elucidate mechanism(s) responsible for overlapping actions of E2-17β and P4 on the liver transcriptome. KEYWORDS: estradiol, progesterone, global gene expression, liver, cows.
2013-04-09 | GSE45857 | GEO
Project description:To identify key genes in the early sex development of zebrafish, we generated zebrafish (AB strain) feminized by sex hormone 17β-estradiol (E2, CAS: 50-28-2, 100 ng/L) and masculinized by aromatase inhibitor exemestane (EM, CAS: 107868-30-4, 10 μg/L), and detected their transcriptomes by RNA-seq.
2022-05-11 | GSE126039 | GEO
Project description:Effect of 17 β-estradiol on developing zebrafish embryos
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Project description:Analysis of Unique and Overlapping Patterns of Gene Expression After Treatment of Zebrafish Embryos with Estradiol and/or Dioxin
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