Dataset Information


Francisella tularensis subsp. mediasiatica FSC147

ABSTRACT: Causative agent of tularemia

ORGANISM(S): Francisella tularensis subsp. mediasiatica FSC147  



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Molecular evolutionary consequences of niche restriction in Francisella tularensis, a facultative intracellular pathogen.

Larsson Pär P   Elfsmark Daniel D   Svensson Kerstin K   Wikström Per P   Forsman Mats M   Brettin Thomas T   Keim Paul P   Johansson Anders A  

PLoS pathogens 20090612 6

Francisella tularensis is a potent mammalian pathogen well adapted to intracellular habitats, whereas F. novicida and F. philomiragia are less virulent in mammals and appear to have less specialized lifecycles. We explored adaptations within the genus that may be linked to increased host association, as follows. First, we determined the genome sequence of F. tularensis subsp. mediasiatica, the only subspecies that had not been previously sequenced. This genome, and those of 12 other F. tularensi  ...[more]

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