Dataset Information


Mus musculus

ABSTRACT: Six2CrefSall1 E14.5 WTvsKO, Sall1CreERfSall1 E14.5 WTvsKO 100120

ORGANISM(S): Mus musculus  



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Sall1 maintains nephron progenitors and nascent nephrons by acting as both an activator and a repressor.

Kanda Shoichiro S   Tanigawa Shunsuke S   Ohmori Tomoko T   Taguchi Atsuhiro A   Kudo Kuniko K   Suzuki Yutaka Y   Sato Yuki Y   Hino Shinjiro S   Sander Maike M   Perantoni Alan O AO   Sugano Sumio S   Nakao Mitsuyoshi M   Nishinakamura Ryuichi R  

Journal of the American Society of Nephrology : JASN 20140417 11

The balanced self-renewal and differentiation of nephron progenitors are critical for kidney development and controlled, in part, by the transcription factor Six2, which antagonizes canonical Wnt signaling-mediated differentiation. A nuclear factor, Sall1, is expressed in Six2-positive progenitors as well as differentiating nascent nephrons, and it is essential for kidney formation. However, the molecular functions and targets of Sall1, especially the functions and targets in the nephron progeni  ...[more]

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