Dataset Information


Homo sapiens

ABSTRACT: Gene expressioin signatures at basal level in human lymphoblastoid cell lines with different ataxia telangiectasia-mutated (ATM) genotypes

ORGANISM(S): Homo sapiens  



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Gene expression signatures but not cell cycle checkpoint functions distinguish AT carriers from normal individuals.

Zhang Liwen L   Simpson Dennis A DA   Innes Cynthia L CL   Chou Jeff J   Bushel Pierre R PR   Paules Richard S RS   Kaufmann William K WK   Zhou Tong T  

Physiological genomics 20130813 19

Ataxia telangiectasia (AT) is a rare autosomal recessive disease caused by mutations in the ataxia telangiectasia-mutated gene (ATM). AT carriers with one mutant ATM allele are usually not severely affected although they carry an increased risk of developing cancer. There has not been an easy and reliable diagnostic method to identify AT carriers. Cell cycle checkpoint functions upon ionizing radiation (IR)-induced DNA damage and gene expression signatures were analyzed in the current study to t  ...[more]

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