Genomics

Dataset Information

0

Homo sapiens


ABSTRACT: Targeting IRAK1 as a therapeutic approach for Myelodysplastic Syndrome

PROVIDER: PRJNA198793 | ENA |

REPOSITORIES: ENA

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Publications


Myelodysplastic syndromes (MDSs) arise from a defective hematopoietic stem/progenitor cell. Consequently, there is an urgent need to develop targeted therapies capable of eliminating the MDS-initiating clones. We identified that IRAK1, an immune-modulating kinase, is overexpressed and hyperactivated in MDSs. MDS clones treated with a small molecule IRAK1 inhibitor (IRAK1/4-Inh) exhibited impaired expansion and increased apoptosis, which coincided with TRAF6/NF-κB inhibition. Suppression of IRAK1  ...[more]

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