Genomics,Multiomics

Dataset Information

0

Homo sapiens


ABSTRACT: Differentially expressed transcripts in SLE blood monocytes

PROVIDER: PRJNA203040 | ENA |

REPOSITORIES: ENA

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Publications


Blood monocytes from children with systemic lupus erythematosus (SLE) behave similar to dendritic cells (DCs), and SLE serum induces healthy monocytes to differentiate into DCs in a type I IFN-dependent manner. In this study, we found that these monocytes display significant transcriptional changes, including a prominent IFN signature, compared with healthy controls. Few of those changes, however, explain DC function. Exposure to allogeneic T cells in vitro reprograms SLE monocytes to acquire DC  ...[more]

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