Genomics

Dataset Information

118

Homo sapiens


ABSTRACT: Functional signature for the recognition of specific target mRNAs by human staufen1 protein

ORGANISM(S): Homo sapiens  

PROVIDER: PRJNA205165 | ENA |

REPOSITORIES: ENA

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Publications

Functional signature for the recognition of specific target mRNAs by human Staufen1 protein.

de Lucas Susana S   Oliveros Juan Carlos JC   Chagoyen Mónica M   Ortín Juan J  

Nucleic acids research 20140126 7


Cellular messenger RNAs (mRNAs) are associated to proteins in the form of ribonucleoprotein particles. The double-stranded RNA-binding (DRB) proteins play important roles in mRNA synthesis, modification, activity and decay. Staufen is a DRB protein involved in the localized translation of specific mRNAs during Drosophila early development. The human Staufen1 (hStau1) forms RNA granules that contain translation regulation proteins as well as cytoskeleton and motor proteins to allow the movement o  ...[more]

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