Genomics

Dataset Information

0

Homo sapiens


ABSTRACT: Identification of differentially expressed genes due to LBH589 treatment in aromatase inhibitor-resistant tumors

ORGANISM(S): Homo sapiens  

PROVIDER: PRJNA205203 | ENA |

REPOSITORIES: ENA

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Publications

BD-Func: a streamlined algorithm for predicting activation and inhibition of pathways.

Warden Charles D CD   Kanaya Noriko N   Chen Shiuan S   Yuan Yate-Ching YC  

PeerJ 20130912


BD-Func (BiDirectional FUNCtional enrichment) is an algorithm that calculates functional enrichment by comparing lists of pre-defined genes that are known to be activated versus inhibited in a pathway or by a regulatory molecule. This paper shows that BD-Func can correctly predict cell line alternations and patient characteristics with accuracy comparable to popular algorithms, with a significantly faster run-time. BD-Func can compare scores for individual samples across multiple groups as well  ...[more]

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