Genomics

Dataset Information

59

Homo sapiens


ABSTRACT: Targeting BCL-2 with the BH3 mimetic ABT-199 in ER-positive breast cancer

ORGANISM(S): Homo sapiens  

PROVIDER: PRJNA205300 | ENA |

REPOSITORIES: ENA

altmetric image

Publications


The prosurvival protein BCL-2 is frequently overexpressed in estrogen receptor (ER)-positive breast cancer. We have generated ER-positive primary breast tumor xenografts that recapitulate the primary tumors and demonstrate that the BH3 mimetic ABT-737 markedly improves tumor response to the antiestrogen tamoxifen. Despite abundant BCL-XL expression, similar efficacy was observed with the BCL-2 selective inhibitor ABT-199, revealing that BCL-2 is a crucial target. Unexpectedly, BH3 mimetics were  ...[more]

Similar Datasets

2008-05-01 | GSE10841 | GEO
2008-06-19 | E-GEOD-10841 | ArrayExpress
2013-11-06 | E-GEOD-48601 | ArrayExpress
2019-01-29 | PXD010217 | Pride
2013-04-03 | E-GEOD-36938 | ArrayExpress
| GSE79955 | GEO
2011-07-01 | GSE25613 | GEO
2011-07-01 | E-GEOD-25613 | ArrayExpress
| GSE95809 | GEO
| GSE93985 | GEO