Dataset Information


Mus musculus

ABSTRACT: Microarray expression profiling of distinct subsets of mouse mammary epithelial cells

ORGANISM(S): Mus musculus  



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RUNX1, a transcription factor mutated in breast cancer, controls the fate of ER-positive mammary luminal cells.

van Bragt Maaike P A MP   Hu Xin X   Xie Ying Y   Li Zhe Z  

eLife 20141121

RUNX1 encodes a RUNX family transcription factor (TF) and was recently identified as a novel mutated gene in human luminal breast cancers. We found that Runx1 is expressed in all subpopulations of murine mammary epithelial cells (MECs) except the secretory alveolar luminal cells. Conditional knockout of Runx1 in MECs by MMTV-Cre led to a decrease in luminal MECs, largely due to a profound reduction in the estrogen receptor (ER)-positive mature luminal subpopulation, a phenotype that could be res  ...[more]

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