Genomics

Dataset Information

59

Homo sapiens


ABSTRACT: MicroRNA expression array for 1833 cells expressing RKIP vs. control

ORGANISM(S): Homo sapiens  

PROVIDER: PRJNA205364 | ENA |

REPOSITORIES: ENA

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Publications

RKIP and HMGA2 regulate breast tumor survival and metastasis through lysyl oxidase and syndecan-2.

Sun M M   Gomes S S   Chen P P   Frankenberger C A CA   Sankarasharma D D   Chung C H CH   Chada K K KK   Rosner M R MR  

Oncogene 20130826 27


Elucidating targets of physiological tumor metastasis suppressors can highlight key signaling pathways leading to invasion and metastasis. To identify downstream targets of the metastasis suppressor Raf-1 kinase inhibitory protein (RKIP/PEBP1), we utilized an integrated approach based upon statistical analysis of tumor gene expression data combined with experimental validation. Previous studies from our laboratory identified the architectural transcription factor and oncogene, high mobility grou  ...[more]

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