Dataset Information


Homo sapiens

ABSTRACT: Gene expression data from 1833 cells expressing RKIP vs control

ORGANISM(S): Homo sapiens  



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RKIP and HMGA2 regulate breast tumor survival and metastasis through lysyl oxidase and syndecan-2.

Sun M M   Gomes S S   Chen P P   Frankenberger C A CA   Sankarasharma D D   Chung C H CH   Chada K K KK   Rosner M R MR  

Oncogene 20130826 27

Elucidating targets of physiological tumor metastasis suppressors can highlight key signaling pathways leading to invasion and metastasis. To identify downstream targets of the metastasis suppressor Raf-1 kinase inhibitory protein (RKIP/PEBP1), we utilized an integrated approach based upon statistical analysis of tumor gene expression data combined with experimental validation. Previous studies from our laboratory identified the architectural transcription factor and oncogene, high mobility grou  ...[more]

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