Genomics

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ABSTRACT: Epigenomic Approaches to explaining Metabolic Memory in the Epidemiology of Diabetes Intervention and Complications (EDIC) Study

PROVIDER: PRJNA205393 | ENA |

REPOSITORIES: ENA

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We assessed whether epigenetic histone posttranslational modifications are associated with the prolonged beneficial effects (metabolic memory) of intensive versus conventional therapy during the Diabetes Control and Complications Trial (DCCT) on the progression of microvascular outcomes in the long-term Epidemiology of Diabetes Interventions and Complications (EDIC) study. We performed chromatin immunoprecipitation linked to promoter tiling arrays to profile H3 lysine-9 acetylation (H3K9Ac), H3  ...[more]

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