Project description:Chromatin immunoprecipitation linked to tiling arrays (ChIP-chip) were performed to profile histone H3K4Me3 at 22K gene promoters in peripheral blood lymphocytes obtained in 2009-10 from 60 selected DCCT participants being followed in the long-term observational EDIC study. Comparison of histone H3K4Me3 at 22K gene promoters in 60 peripheral blood lymphocytes samples obtained from the conventional and intensive therapy DCCT groups
Project description:Chromatin immunoprecipitation linked to tiling arrays (ChIP-chip) were performed to profile histone H3K4Me3 at 22K gene promoters in peripheral blood monocytes obtained in 2009-10 from 60 selected DCCT participants being followed in the long-term observational EDIC study. Comparison of histone H3K4Me3 at 22K gene promoters in 60 peripheral blood monocytes samples obtained from the conventional and intensive therapy DCCT groups
Project description:Chromatin immunoprecipitation linked to tiling arrays (ChIP-chip) were performed to profile histone H3K4Me3 at 22K gene promoters in peripheral blood monocytes obtained in 2009-10 from 60 selected DCCT participants being followed in the long-term observational EDIC study.
Project description:Chromatin immunoprecipitation linked to tiling arrays (ChIP-chip) were performed to profile histone H3K4Me3 at 22K gene promoters in peripheral blood lymphocytes obtained in 2009-10 from 60 selected DCCT participants being followed in the long-term observational EDIC study.
Project description:Study the association of DNA-methylation and metabolic memory by examing DNA-methylation alternation between cases (received conventional therapy in DCCT and showing retinopathy or albuminuria progression at EDIC year-10) and Controls(in DCCT intensive treatment group and did not have retinopathy or nephropathy progression during EDIC] Bisulphite converted DNA from the 61 monocyte samples (31 Cases and 30 Controls) were hybridised to the Illumina Infinium HumanMethylation450 Beadchip arrays. Please note that the same samples were used on histone-modification profilling in PMID:24458354
Project description:Study the association of DNA-methylation and metabolic memory by examing DNA-methylation alternation between cases (received conventional therapy in DCCT and showing retinopathy or albuminuria progression at EDIC year-10) and Controls(in DCCT intensive treatment group and did not have retinopathy or nephropathy progression during EDIC]