Genomics

Dataset Information

0

Homo sapiens


ABSTRACT: Smoking Dysregulates the Human Airway Basal Cell Transcriptome at COPD-linked Risk Locus 19q13.2

ORGANISM(S): Homo sapiens  

PROVIDER: PRJNA207365 | ENA |

REPOSITORIES: ENA

Dataset's files

Source:
Action DRS
SRR886565_1.fastq.gz Fastqsanger.gz
SRR886565_2.fastq.gz Fastqsanger.gz
SRR886566_1.fastq.gz Fastqsanger.gz
SRR886566_2.fastq.gz Fastqsanger.gz
SRR886567_1.fastq.gz Fastqsanger.gz
Items per page:
1 - 5 of 104
altmetric image

Publications


Genome-wide association studies (GWAS) and candidate gene studies have identified a number of risk loci associated with the smoking-related disease COPD, a disorder that originates in the airway epithelium. Since airway basal cell (BC) stem/progenitor cells exhibit the earliest abnormalities associated with smoking (hyperplasia, squamous metaplasia), we hypothesized that smoker BC have a dysregulated transcriptome, enriched, in part, at known GWAS/candidate gene loci. Massive parallel RNA sequen  ...[more]

Similar Datasets

| GSE47718 | GEO
2014-05-08 | E-GEOD-47718 | ArrayExpress
2019-05-14 | E-GEOD-47718 | ExpressionAtlas
2018-04-04 | GSE86064 | GEO
2014-01-01 | S-EPMC3912203 | BioStudies
2017-07-18 | GSE64614 | GEO
2020-01-01 | S-EPMC7499856 | BioStudies
2015-11-23 | E-GEOD-53519 | ArrayExpress
1000-01-01 | S-EPMC4629722 | BioStudies
2005-10-30 | GSE3320 | GEO