Dataset Information


Mus musculus

ABSTRACT: The AP-1 Transcription Factor c-Jun Prevents Stress-Imposed Maladaptive Remodeling of the Heart

ORGANISM(S): Mus musculus  



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The AP-1 transcription factor c-Jun prevents stress-imposed maladaptive remodeling of the heart.

Windak Renata R   Müller Julius J   Felley Allison A   Akhmedov Alexander A   Wagner Erwin F EF   Pedrazzini Thierry T   Sumara Grzegorz G   Ricci Romeo R  

PloS one 20130910 9

Systemic hypertension increases cardiac workload and subsequently induces signaling networks in heart that underlie myocyte growth (hypertrophic response) through expansion of sarcomeres with the aim to increase contractility. However, conditions of increased workload can induce both adaptive and maladaptive growth of heart muscle. Previous studies implicate two members of the AP-1 transcription factor family, junD and fra-1, in regulation of heart growth during hypertrophic response. In this st  ...[more]

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