Dataset Information


Mus musculus

ABSTRACT: Genome-wide analysis of liver gene expression in male and female mice.

ORGANISM(S): Mus musculus  



altmetric image


Sexually dimorphic genome-wide binding of retinoid X receptor alpha (RXRα) determines male-female differences in the expression of hepatic lipid processing genes in mice.

Kosters Astrid A   Sun Deqiang D   Wu Hao H   Tian Feng F   Felix Julio C JC   Li Wei W   Karpen Saul J SJ  

PloS one 20130819 8

Many hepatic functions including lipid metabolism, drug metabolism, and inflammatory responses are regulated in a sex-specific manner due to distinct patterns of hepatic gene expression between males and females. Regulation for the majority of these genes is under control of Nuclear Receptors (NRs). Retinoid X Receptor alpha (RXRα) is an obligate partner for multiple NRs and considered a master regulator of hepatic gene expression, yet the full extent of RXRα chromatin binding in male and female  ...[more]

Similar Datasets

2010-01-27 | GSE17644 | GEO
2012-09-10 | E-GEOD-35897 | ArrayExpress
2012-04-04 | GSE34782 | GEO
2012-04-03 | E-GEOD-34782 | ArrayExpress
2012-09-10 | E-GEOD-37078 | ArrayExpress
2014-12-04 | E-GEOD-61417 | ArrayExpress
| PRJNA132979 | ENA
2014-05-01 | E-GEOD-54089 | ArrayExpress
| PRJNA208936 | ENA
| PRJNA208273 | ENA