Dataset Information


Mus musculus

ABSTRACT: Maintenance of DNA methylation in embryonic stem cells depends on the histone H3K9 methyltransferases (Dnmt3ab KO Methyl-Seq)

ORGANISM(S): Mus musculus  



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Regulation of DNA methylation turnover at LTR retrotransposons and imprinted loci by the histone methyltransferase Setdb1.

Leung Danny D   Du Tingting T   Wagner Ulrich U   Xie Wei W   Lee Ah Young AY   Goyal Preeti P   Li Yujing Y   Szulwach Keith E KE   Jin Peng P   Lorincz Matthew C MC   Ren Bing B  

Proceedings of the National Academy of Sciences of the United States of America 20140422 18

During mammalian development, DNA methylation patterns need to be reset in primordial germ cells (PGCs) and preimplantation embryos. However, many LTR retrotransposons and imprinted genes are impervious to such global epigenetic reprogramming via hitherto undefined mechanisms. Here, we report that a subset of such genomic regions are resistant to widespread erasure of DNA methylation in mouse embryonic stem cells (mESCs) lacking the de novo DNA methyltransferases (Dnmts) Dnmt3a and Dnmt3b. Intri  ...[more]

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