Genomics

Dataset Information

247

Analysis of tumor- and stroma-supplied proteolytic networks in different metastatic tumor microenvironments identifies a critical role for cathepsin S in brain metastasis


ABSTRACT: Analysis of tumor- and stroma-supplied proteolytic networks in different metastatic tumor microenvironments identifies a critical role for cathepsin S in brain metastasis

PROVIDER: PRJNA208376 | ENA |

REPOSITORIES: ENA

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Analysis of tumour- and stroma-supplied proteolytic networks reveals a brain-metastasis-promoting role for cathepsin S.

Sevenich Lisa L   Bowman Robert L RL   Mason Steven D SD   Quail Daniela F DF   Rapaport Franck F   Elie Benelita T BT   Brogi Edi E   Brastianos Priscilla K PK   Hahn William C WC   Holsinger Leslie J LJ   Massagué Joan J   Leslie Christina S CS   Joyce Johanna A JA  

Nature cell biology 20140803 9


Metastasis remains the most common cause of death in most cancers, with limited therapies for combating disseminated disease. While the primary tumour microenvironment is an important regulator of cancer progression, it is less well understood how different tissue environments influence metastasis. We analysed tumour-stroma interactions that modulate organ tropism of brain, bone and lung metastasis in xenograft models. We identified a number of potential modulators of site-specific metastasis, i  ...[more]

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