Dataset Information


Homo sapiens

ABSTRACT: Gene expression profiles of Siglec-14/THP-1 and Siglec-5/THP cell lines, with or without NTHi stimulation

ORGANISM(S): Homo sapiens  



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Association of serum interleukin-27 with the exacerbation of chronic obstructive pulmonary disease.

Angata Takashi T   Ishii Takeo T   Gao Congxiao C   Ohtsubo Kazuaki K   Kitazume Shinobu S   Gemma Akihiko A   Kida Kozui K   Taniguchi Naoyuki N  

Physiological reports 20140703 7

We have previously demonstrated that chronic obstructive pulmonary disease (COPD) patients who do not have Siglec-14 are less prone to exacerbation of the disease. Siglec-14 is a myeloid cell protein that recognizes bacteria and triggers inflammatory responses. Therefore, soluble mediators secreted by myeloid cells responding to Siglec-14 engagement could be involved in the pathogenesis of exacerbation and could potentially be utilized as biomarkers of exacerbation. To find out, we sought genes  ...[more]

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