Genomics

Dataset Information

0

Homo sapiens


ABSTRACT: Genetic mapping with multiple levels of phenotypic information reveals new determinants of lymphocyte glucocorticoid sensitivity

ORGANISM(S): Homo sapiens  

PROVIDER: PRJNA211814 | ENA |

REPOSITORIES: ENA

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Publications

Genetic mapping with multiple levels of phenotypic information reveals determinants of lymphocyte glucocorticoid sensitivity.

Maranville Joseph C JC   Baxter Shaneen S SS   Witonsky David B DB   Chase Meredith A MA   Di Rienzo Anna A  

American Journal of Human Genetics 20130919 4


Clinical response to glucocorticoids, steroid hormones widely used as pharmaceuticals, varies extensively in that many individuals (∼30%) show a weak response to treatment. Although little is known about the molecular basis of this variation, regulatory polymorphisms are likely to play a key role given that glucocorticoids act largely through activation of a transcription factor, the glucocorticoid receptor. In an effort to characterize the molecular basis of variation in glucocorticoid sensitiv  ...[more]

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