Genomics

Dataset Information

235

The metabolic niche of a prominent sulfate-reducing human gut bacterium [2]


ABSTRACT: The metabolic niche of a prominent sulfate-reducing human gut bacterium [2]

PROVIDER: PRJNA211823 | ENA |

REPOSITORIES: ENA

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Metabolic niche of a prominent sulfate-reducing human gut bacterium.

Rey Federico E FE   Gonzalez Mark D MD   Cheng Jiye J   Wu Meng M   Ahern Philip P PP   Gordon Jeffrey I JI  

Proceedings of the National Academy of Sciences of the United States of America 20130729 33


Sulfate-reducing bacteria (SRB) colonize the guts of ∼50% of humans. We used genome-wide transposon mutagenesis and insertion-site sequencing, RNA-Seq, plus mass spectrometry to characterize genetic and environmental factors that impact the niche of Desulfovibrio piger, the most common SRB in a surveyed cohort of healthy US adults. Gnotobiotic mice were colonized with an assemblage of sequenced human gut bacterial species with or without D. piger and fed diets with different levels and types of  ...[more]

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