Dataset Information


Homo sapiens

ABSTRACT: Genome-wide transcriptome analysis of the dietary chemopreventive phytochemical sulforaphane on normal and prostate cancer cells.

ORGANISM(S): Homo sapiens  



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Transcriptome analysis reveals a dynamic and differential transcriptional response to sulforaphane in normal and prostate cancer cells and suggests a role for Sp1 in chemoprevention.

Beaver Laura M LM   Buchanan Alex A   Sokolowski Elizabeth I EI   Riscoe Allison N AN   Wong Carmen P CP   Chang Jeff H JH   Löhr Christiane V CV   Williams David E DE   Dashwood Roderick H RH   Ho Emily E  

Molecular nutrition & food research 20140805 10

Epidemiological studies provide evidence that consumption of cruciferous vegetables, like broccoli, can reduce the risk of cancer development. Sulforaphane (SFN) is a phytochemical derived from cruciferous vegetables that induces anti-proliferative and pro-apoptotic responses in prostate cancer cells, but not in normal prostate cells. The mechanisms responsible for this cancer-specific cytotoxicity remain unclear.We utilized RNA sequencing and determined the transcriptomes of normal prostate epi  ...[more]

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