Dataset Information


Mus musculus

ABSTRACT: Visceral obesity in murine pregnancy

ORGANISM(S): Mus musculus  



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Pregnancy in obese mice protects selectively against visceral adiposity and is associated with increased adipocyte estrogen signalling.

Pedroni Silvia M A SM   Turban Sophie S   Kipari Tiina T   Dunbar Donald R DR   McInnes Kerry K   Saunders Philippa T K PT   Morton Nicholas M NM   Norman Jane E JE  

PloS one 20140414 4

Maternal obesity is linked with increased adverse pregnancy outcomes for both mother and child. The metabolic impact of excessive fat within the context of pregnancy is not fully understood. We used a mouse model of high fat (HF) feeding to induce maternal obesity to identify adipose tissue-mediated mechanisms driving metabolic dysfunction in pregnant and non-pregnant obese mice. As expected, chronic HF-feeding for 12 weeks preceding pregnancy increased peripheral (subcutaneous) and visceral (me  ...[more]

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